Ub-VS:a potent and specific inhibitor of deubiquitinating enzymes (DUBs)。一種有效的特異性去泛素化酶 (DUB) 抑制劑。
code: UbiQ-108
category: activity-based probes
applications:
crystallization, purification, western blot, phenotypic protein profiling, dub activity profiling
英文描述:
Ubiquitin-Viny Sulfone (UbiQ-108) is a potent and specific inhibitor of deubiquitinating enzymes (DUBs). This activity probe can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets all two of the major DUB families: USP and OTU.
中文描述:
Ubiquitin-Viny Sulfone (UbiQ-108) 是一種有效的特異性去泛素化酶 (DUB) 抑制劑。該活性探針可用于活性分析實(shí)驗(yàn)和確定 DUB 抑制劑特異性。它針對(duì)所有兩個(gè)主要的 DUB 系列:USP 和 OTU。
產(chǎn)品文獻(xiàn):
1.Galardy, P., et al. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. Methods in Enzymology. 399, 120-131 (2005).
ncbi.nlm.nih.gov/pubmed/16338352
2. de Jong, A., et al. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. ChemBiochem 13, 2251-2258 (2012).
ncbi.nlm.nih.gov/pubmed/23011887
3. Wrigley, J.D. et al. Enzymatic characterisation of USP7 deubiquitinating activity and inhibition. Cell Biochem. Biophys. 60, 99-111 (2011)
ncbi.nlm.nih.gov/pubmed/21468692
靶點(diǎn)科技(北京)有限公司
地址:中關(guān)村生命科學(xué)園北清創(chuàng)意園2-4樓2層
© 2024 版權(quán)所有:靶點(diǎn)科技(北京)有限公司 備案號(hào):京ICP備18027329號(hào)-2 總訪問量:256418 站點(diǎn)地圖 技術(shù)支持:化工儀器網(wǎng) 管理登陸